Anterior horn lesion of spinal cord as the initial manifestation of multiple myeloma: A case report

Yu Feng, Hongmei Ding, Xiaolong Wang, Ruiguo Dong, Deqin Geng

Abstract


Multiple myeloma (MM) is a malignant proliferation of abnormal plasma cell tumour that often violates multiple body systems. Its clinical manifestations vary greatly, thus leading to a high rate of misdiagnosis. Herein, we report a clinical case of non-compressive spinal cord lesion, which manifested early signs of multiple myeloma. Retrospective analyses of MM pathogenesis, clinical manifestation, and diagnosis were based on the clinical features and diagnostic criteria of MM that have been published in the literature. This study was initiated to improve current awareness of MM and to reduce the rate of misdiagnosis.

Keywords


multiple myeloma; anterior horn lesion of spinal cord; misdiagnosis

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References


Medical Research Council. Aids to the examination of the peripheral nervous system. London: Her Majesty’s Stationery Office; 1976. p. 1–61.

Acton Q. Multiple myeloma: New insights for the healthcare professional: 2011 edition. USA: Scholarly Editions; 2012.

Wildes TM, Campagnaro E. Management of multiple myeloma in older adults: Gaining ground with geriatric assessment. J Geriatr Oncol 2016. In Press. doi: 10.1016/ j.jgo.2016.04.001.

International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group. Br J Haematol 2003; 121(5): 749–757. doi: 10.1046/j.1365-2141.2003.04355.x.

Moehler T, Goldschmidt H. Multiple myeloma. Berlin: Springer-Verlag Berlin Heidelberg; 2011. doi: 10.1007/ 978-3-540-85772-3.

Bladé J, Lust JA, Kyle RA. Immunoglobulin D multiple myeloma: Presenting features, response to therapy and survival in a series of 53 cases. J Clin Oncol 1994; 12(11): 2398–2404. doi: 10.1200/JCO.1994.12.11.2398.

Zhou J, Tang H, Wang J. Misdiagnosis of multiple myeloma: A meta-analysis. Chin Leuk Lymphoma 2013, 22(8): 483–486. doi: 10.3760/cma.j.issn.1009-9921.2013.08.010.

Zuo X, Huang J, Zeng X. Neuropathy as the first manifestation of multiple myeloma. Chin J Brain Nerv Dis 2002; 10(6): 354–356.

Rison RA, Beydoun SR. Paraproteinemic neuropathy: A practical review. BMC Neurol 2016; 16: 13. doi: 10.1186/s12883-016-0532-4.

Sun H, Guo X. A report of 46 cases of hematologic disorders with neurologic symptoms as initial manifestations. Chin J Intern Intensive Med 1999; 5(1): 12–13.

Hussein M. Chapter 13—Multiple myeloma and plasmacytoma. In: McLain RF, Lewandrowski KU, Markman M, et al., (editors). Cancer in the spine. USA: Humana Press; 2006. p. 101–106. doi: 10.1007/978-1-59259-971-4_13.

Velasco R, Bruna J. Neurologic complications in multiple myeloma and plasmacytoma. Eur Assoc Neuro Oncol Mag 2012; 2(2): 71–77.

Lonial S. Presentation and risk stratification—Improving prognosis for patients with multiple myeloma. Cancer Treat Rev 2010; 36(Suppl 2): S12–S17. doi: 10.1016/ S0305-7372(10)70007-4.t.




DOI: http://dx.doi.org/10.30564/amor.v2i6.94

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