Surgical Procedures, Pathological Features and Prognosis in Young Women with Breast Cancer in China – a Single Institute Experience

Haili Lu, Tatsiana Paliyenka, Jing Han

Abstract


Objective: To compare the differences in surgical procedures, pathological features and prognosis between young and elderly women with breast cancer in China. Methods: A retrospective study compared the data of surgical procedures, pathological features and prognosis of 61 cases of young females (≤ 40 years) and 507 cases of elderly females (> 40 years), treated in our department from August 2011 to July 2018. This data was analyzed using SPSS 23.0 program. Results: 10.74% of total cases, in this period of time, involve young females. In terms of surgical procedures, 24.59% of young patients underwent breast conserving surgery (8.48% elderly, respectively), and 13.11% underwent reconstruction surgery (1.18% elderly, respectively), with statistically significant differences existing between the two groups (P < 0.05). Progesterone receptor (PR) expression in young women was significantly higher than in elderly females (P < 0.05). There were no significant differences between the two groups in the proportion of invasive ductal carcinoma (IDC), axillary lymph node metastasis (ALNM), expression of estrogen receptor (ER), human epidermal growth factor receptor-2 (HER-2) and Ki-67, but the lymphatic metastasis stage showed an increasing rate with younger age. No significant difference was found in 3-year disease-free survival (DFS) and overall survival (OS). Conclusion: The selection rate of breast conserving and reconstructive surgery in young women with breast cancer is significantly higher than that in elderly women. The younger the patient, the more frequently the PR positive expression, and the more likely ALNM to occur. The 3-year prognosis of the young and elderly patients is similar.


Keywords


Breast neoplasm; Young women; Surgical procedures; Pathological features

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References


Ghoncheh M, Pournamdar Z, Salehiniya H. Incidence and Mortality and Epidemiology of Breast Cancer in the World. Asian Pacific Journal of Cancer Prevention Apjcp 2016,17(S3):p.43-6.

Hongmei Z, Rongshou Z, Siwei Z, et al. Female breast cancer statistics of 2010 in China: estimates based on data from 145 population-based cancer registries. Journal of Thoracic Disease 2014,6(5):p.466-70.

Gómez-Flores-Ramos L, Álvarez-Gómez RM, Villarreal-Garza C, et al. BREAST CANCER GENETICS IN YOUNG WOMEN: WHAT DO WE KNOW?. Mutation Research/reviews in Mutation Research 2017,774:p.33-45.

Paluch-Shimon S, Pagani O, Partridge A H, et al. ESO-ESMO 3rd international consensus guidelines for breast cancer in young women (BCY3). Breast 2017,35:203-17.

Breast Cancer Diagnosis and Treatment Guidelines of Chinese Society of Clinical Oncology.Version 1. 2018.

Qing-Kun S, Jing L, Rong H, et al. Age of diagnosis of breast cancer in china: almost 10 years earlier than in the United States and the European union. Asian Pacific Journal of Cancer Prevention Apjcp 2014,15(22):10021-5.

Lee H B, Han W. Unique features of young age breast cancer and its management. Journal of Breast Cancer 2014,7(4):301-7.

Han W, Kim S W, Park I A, et al. Young age: an independent risk factor for disease-free survival in women with operable breast cancer. Bmc Cancer 2004,4(1):82.

Fan L, Strasser-Weippl K, Li JJ, et al. Breast cancer in China. Lancet Oncology 2014,15(7):p.279-89.

Radecka B, Litwiniuk M. Breast cancer in young women.Ginekologia Polska 2016,87(9):659-63.

Han J G, Jiang Y D, Zhang C H, et al. Clinicopathologic characteristics and prognosis of young patients with breast cancer. Breast 2011,20(4):370-72.

Bibhusal T, Yogendra S, Prakash S, et al. Breast cancer in young women from a low risk population in Nepal. Asian Pacific Journal of Cancer Prevention 2013,14(9):p.5095-9.

VÖ. Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients). J Breast Health 2014,10(2):p.98-105.

Recio-Saucedo A, Gerty S, Foster C, et al. Information requirements of young women with breast cancer treated with mastectomy or breast conserving surgery: A systematic review. Breast 2016,25:1-13.

Azim HA, Partridge AH. Biology of breast cancer in young women. Breast Cancer Research 2014,16(4):427.

Dubsky PC, Gnant MFX, Taucher S, et al. Young Age as an Independent Adverse Prognostic Factor in Premenopausal Patients with Breast Cancer. Clinical Breast Cancer 2003,3(1):65-72.

Ye J C, Yan W, Christos P J, et al. Equivalent Survival With Mastectomy or Breast-conserving Surgery Plus Radiation in Young Women Aged< 40 Years With Early-Stage Breast Cancer: A National Registry-based Stage-by-Stage Comparison. Clinical Breast Cancer 2015,15(5):390-7.

Jose V, Sara G, Oreste G. Overall survival according to type of surgery in young (≤40 years) early breast cancer patients: A systematic meta-analysis comparing breast-conserving surgery versus mastectomy. Breast 2015,24(3):175-81.

Meng-Qing S, Ai-Feng M, Xin-En H, et al. Comparison of psychological influence on breast cancer patients between breast-conserving surgery and modified radical mastectomy. Asian Pacific Journal of Cancer Prevention 2013,14(1):149-52.

Han J, Grothuesmann D, Neises M, et al. Quality of life and satisfaction after breast cancer operation. Archives of Gynecology & Obstetrics 2010,282(1):75-82.

EmiroäŸLu M, Karaali C, Sert Ä, et al. Comparison of Clinical and Pathological Differences of Breast Cancer Patients under 35 and above 55 Years of Age. J Breast Health 2015,11(3):p.123-7.

Lee SB, Lee JW, Son BH, et al. Oncologic safety of skin-sparing mastectomy followed by immediate reconstruction in young patients with breast cancer. Asian Journal of Surgery 2018,42(1):274-82.

Fanakidou I, Zyga S, Alikari V, et al. Mental health, loneliness, and illness perception outcomes in quality of life among young breast cancer patients after mastectomy:the role of breast reconstruction. Quality of Life Research 2018,27(2):1-5.

Ho AY, Hu ZI, Mehrara BJ, et al. Radiotherapy in the setting of breast reconstruction: types, techniques, and timing.Lancet Oncology 2017,18(12):e742-e753.

Nahabedian MY. Implant-based breast reconstruction:Strategies to achieve optimal outcomes and minimize complications. Journal of Surgical Oncology 2016,113(8):895-905.

Jung SY, Han W, Lee JW, et al. Ki-67 Expression Gives Additional Prognostic Information on St. Gallen 2007 and Adjuvant! Online Risk Categories in Early Breast Cancer.Annals of Surgical Oncology 2009,16(5):1112-21.

Qingli Z, Baohua M, Min K. A retrospective comparative study of clinicopathological features between young and elderly women with breast cancer. International Journal of Clinical & Experimental Medicine 2015,8(4):5869-75.

Yu KD, Shao ZM. A straightforward but not piecewise relationship between age and lymph node status in Chinese breast cancer patients. Plos One 2010,5(6):96-7.

Cheng-Har Y, Anthony R. Estrogen and progesterone receptors in breast cancer. Future Oncology 2014,10(14):2293-301.

Nordenskjöld A, Fohlin H, Fornander T, et al. Progesterone receptor positivity is a predictor of long-term benefit from adjuvant tamoxifen treatment of estrogen receptor positive breast cancer. Breast Cancer Research & Treatment 2016,160(2):313-22.

Mcfall T, Mcknight B, Rosati R, et al. Progesterone Receptor A Promotes Invasiveness and Metastasis of Luminal Breast Cancer by Suppressing Regulation of Critical Micro RNAs by Estrogen. Journal of Biological Chemistry 2018,293(4):1163-77.

Singhal H, Greene ME, Zarnke AL, et al. Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signaling. Oncotarget 2018,9(4):4282-300.

Kataoka A, Tokunaga E, Masuda N, et al. Clinicopathological features of young patients (<35 years of age) with breast cancer in a Japanese Breast Cancer Society supported study. Breast Cancer 2014,21(6):643-50.

Ankit Bharat MD, Aft RL, Feng G, et al. Patient and tumor characteristics associated with increased mortality in young women (≤40 years) with breast cancer. Journal of Surgical Oncology 2009,100(3):248-51.

Sidoni A, Cavaliere A, Bellezza G, et al. Breast cancer in young women: clinicopathological features and biological specificity. Breast 2003,12(4):247-50.

Ke W, Yu R, Li H, et al. Comparison of Clinicopathological Features and Treatments between Young (≤40 Years) and Older (>40 Years) Female Breast Cancer Patients in West China: A Retrospective, Epidemiological, Multicenter,Case Only Study. Plos One 2016,11(3):e0152312.

Matteo L, Massimo DM, Olivia P, et al. The BCY3/BCC 2017 survey on physicians' knowledge, attitudes and practice towards fertility and pregnancy-related issues in young breast cancer patients. The Breast 2018,42:41-9.




DOI: http://dx.doi.org/10.30564/amor.v4i5.187

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